Hentschel Michael, Paul Dominik, Korsten-Reck Ulrike, Mix Michael, Müller Frank, Merk Stefan, Moser Ernst, Brink Ingo
Division of Nuclear Medicine, Section of Positron Emission Tomography, University Hospital Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany.
Eur J Nucl Med Mol Imaging. 2005 May;32(5):564-8. doi: 10.1007/s00259-004-1714-7. Epub 2004 Dec 15.
To avoid dependence on body weight, the standardised uptake value (SUV) in positron emission tomography (PET) can instead be normalised to the lean body mass (LBM), which can be determined from body volume and mass. This study was designed to answer the following questions: Firstly, can the total body volume in principle be determined using PET? Secondly, is the precision of this measurement comparable to that achieved using an established standard method.
Ten patients were examined during oncological whole-body PET examinations. The whole-body volume of the patients was determined from the transmission scan in PET. Air displacement plethysmography with BOD POD was used for comparison as the standard method of volume determination.
In all patients, the whole-body volumes could be determined using PET and the standard method. Bland and Altman [23] analysis for agreement between the volumes determined by the two methods (presentation of differences vs means) revealed a very small difference of -0.14 l. With a mean patient volume of 71.81+/-15.93 l, the relative systematic error is only <0.1%. On this basis, equality of the volume values determined by the two methods can be assumed.
PET can be used as a supplementary method for experimental determination of whole-body volume and total body fat in tumour patients. The fat content can be used to calculate the LBM and to determine body weight-independent SUVs (SUV(LBM)).
为避免对体重的依赖，正电子发射断层扫描（PET）中的标准化摄取值（SUV）可改为根据瘦体重（LBM）进行标准化，瘦体重可由身体体积和质量确定。本研究旨在回答以下问题：第一，原则上能否使用PET确定全身体积？第二，该测量的精度与使用既定标准方法所达到的精度是否相当？
在肿瘤全身PET检查期间对10名患者进行了检查。通过PET中的透射扫描确定患者的全身体积。使用BOD POD进行空气置换体积描记法作为体积测定的标准方法进行比较。
在所有患者中，均可使用PET和标准方法确定全身体积。对两种方法测定的体积之间的一致性进行的布兰德和奥特曼[23]分析（差异与均值的呈现）显示差异非常小，为-0.14升。患者平均体积为71.81±15.93升，相对系统误差仅<0.1%。在此基础上，可以假定两种方法测定的体积值相等。
PET可作为一种补充方法，用于实验性测定肿瘤患者的全身体积和全身脂肪。脂肪含量可用于计算瘦体重并确定与体重无关的SUV（SUV（LBM））。
