Wisniewski K, Jervis G A, Moretz R C, Wisniewski H M
Ann Neurol. 1979 Mar;5(3):288-94. doi: 10.1002/ana.410050311.
A brief description is given of neurofibrillary changes of the paired helical filament type in a variety of chronic neurological diseases. These include subacute sclerosing panencephalitis, lead encephalopathy, tuberous sclerosis, Down syndrome, Hallervorden-Spatz disease, and lipofuscinosis. In these conditions, with the exception of Hallervorden-Spatz disease neurofibrillary changes were previously recognized but paired helical filaments were identified only in some cases. Moreover, in the present series, the age of patients at death was often younger than in previously recorded cases.
本文简要描述了多种慢性神经疾病中配对螺旋丝类型的神经原纤维变化。这些疾病包括亚急性硬化性全脑炎、铅中毒性脑病、结节性硬化症、唐氏综合征、哈勒沃登 - 施帕茨病和脂褐质沉积症。在这些病症中，除哈勒沃登 - 施帕茨病外，神经原纤维变化先前已得到确认，但仅在某些病例中鉴定出配对螺旋丝。此外，在本系列研究中，患者的死亡年龄往往比先前记录的病例更年轻。
