Suptel' E A, Zagornaia N B, Bass T M
Antibiotiki. 1979 Mar;24(3):207-10.
It was found that for successful elaboration of effective schemes for the use of antibacterial drugs in treatment of dysentery it was necessary to exploit various experimental models providing consideration of the drug toxicity and effect on the extra- and intracellular growth of the bacteria in addition to the other factors. The administration of enteroceptol for 3 days followed by furazolidon showed the best therapeutic effect in the treatment of guinea pigs with Shigella keratoconjunctivitis and Syrian hamsters with dysentery. The above drugs had low toxicity which was shown in the experiments with Hep-2 cell cultures. It was concluded that the use of the drugs with different modes of action was advisable in treatment of dysentery.
结果发现，要成功制定出治疗痢疾时使用抗菌药物的有效方案，除其他因素外，还必须利用各种实验模型，以考虑药物毒性以及对细菌细胞外和细胞内生长的影响。对患有志贺氏角膜炎的豚鼠和患有痢疾的叙利亚仓鼠进行治疗时，先给予肠ceptol 3天，然后给予呋喃唑酮，显示出最佳治疗效果。上述药物毒性较低，这在Hep - 2细胞培养实验中得到了证明。得出的结论是，在治疗痢疾时，使用具有不同作用方式的药物是可取的。
