Litinskii Y I, Andreyeva Z M, Godovannii B A, Gerok G I, Khalitova E B
J Hyg Epidemiol Microbiol Immunol. 1977;21(1):42-8.
The effect of the preparation of colicin V, freed from the endotoxin of the producer strain E. coli Ca-7 on Sh. sonnei was studied in the keratoconjunctival tests on guinea pigs and in the cell culture Hep-2. Colicin V was found to inhibit the development of dysenteric infection in vivo by delaying the incubation period. It has been demonstrated that the mentioned colicin blocks the process of adsorption of the causative agent on the surface of epithelial cells. Obviously, colicin V can also display bactericidal effect at the moment of intercellular migration of Shigellae, but it has no effect on bacteria which have penetrated into the cytoplasm of epithelial cells. The obtained data support the opinion of the role of colicins played in the development and course of infectious processes.
研究了去除产生菌大肠杆菌Ca - 7内毒素后的大肠菌素V制剂对豚鼠角膜结膜试验及人喉表皮样癌细胞株Hep - 2的作用。发现在体内，大肠菌素V通过延长潜伏期抑制痢疾感染的发展。已经证明，上述大肠菌素能阻断病原体在上皮细胞表面的吸附过程。显然，在志贺氏菌细胞间迁移时，大肠菌素V也可发挥杀菌作用，但对已侵入上皮细胞胞质的细菌无作用。所得数据支持了关于大肠菌素在感染过程的发生和发展中所起作用的观点。
