腹外侧前额叶皮层对听觉刺激的空间和非空间属性的选择性
Selectivity for the spatial and nonspatial attributes of auditory stimuli in the ventrolateral prefrontal cortex.
作者信息
Cohen Yale E, Russ Brian E, Gifford Gordon W, Kiringoda Ruwan, MacLean Katherine A
机构信息
Department of Psychological and Brain Sciences, Dartmouth College, Hanover, New Hampshire 03755, USA.
出版信息
J Neurosci. 2004 Dec 15;24(50):11307-16. doi: 10.1523/JNEUROSCI.3935-04.2004.
Spatial and nonspatial auditory processing is hypothesized to occur in parallel dorsal and ventral pathways, respectively. In this study, we tested the spatial and nonspatial sensitivity of auditory neurons in the ventrolateral prefrontal cortex (vPFC), a cortical area in the hypothetical nonspatial pathway. We found that vPFC neurons were modulated significantly by both the spatial and nonspatial attributes of an auditory stimulus. When comparing these responses with those in anterolateral belt region of the auditory cortex, which is hypothesized to be specialized for processing the nonspatial attributes of auditory stimuli, we found that the nonspatial sensitivity of vPFC neurons was poorer, whereas the spatial selectivity was better than anterolateral neurons. Also, the spatial and nonspatial sensitivity of vPFC neurons was comparable with that seen in the lateral intraparietal area, a cortical area that is a part of the dorsal pathway. These data suggest that substantial spatial and nonspatial processing occurs in both the dorsal and ventral pathways.
空间听觉处理和非空间听觉处理分别被假定在并行的背侧和腹侧通路中进行。在本研究中，我们测试了腹外侧前额叶皮层（vPFC）（假定的非空间通路中的一个皮层区域）中听觉神经元的空间和非空间敏感性。我们发现，听觉刺激的空间和非空间属性均能显著调节vPFC神经元。当将这些反应与听觉皮层前外侧带区域（假定专门用于处理听觉刺激的非空间属性）的反应进行比较时，我们发现vPFC神经元的非空间敏感性较差，而空间选择性优于前外侧神经元。此外，vPFC神经元的空间和非空间敏感性与顶内沟外侧区（背侧通路的一个皮层区域）的情况相当。这些数据表明，背侧和腹侧通路中均存在大量的空间和非空间处理过程。
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