与胆碱能和5-羟色胺能反弹性多动相关的氯氮平戒断性紧张症：一例报告

Clozapine withdrawal catatonia associated with cholinergic and serotonergic rebound hyperactivity: a case report.

作者信息

Yeh Andrew Wei-Chiang, Lee Joseph W Y, Cheng Tsun-Chi, Wen Jung-Kwang, Chen Wei-Hsi

机构信息

Department of General and Adolescent Psychiatry, School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Australia.

出版信息

Clin Neuropharmacol. 2004 Sep-Oct;27(5):216-8. doi: 10.1097/01.wnf.0000145506.99636.1b.

DOI:10.1097/01.wnf.0000145506.99636.1b

PMID:15602101

Abstract

Catatonia as a clozapine withdrawal syndrome has not been well documented. There is only 1 case of excited catatonia described with the diagnosis made according to strict criteria. The authors report a patient who developed a catatonic stuporous state following abrupt discontinuation of clozapine, associated with features of cholinergic and serotonergic hyperactivity. The catatonic state resolved within 1 week with reinstatement of clozapine. It is suggested that serotonergic hyperactivity was involved, contributed by cholinergic rebound, in the pathogenesis of this patient's clozapine withdrawal catatonic syndrome.

摘要

作为氯氮平戒断综合征的紧张症尚未得到充分记录。仅有1例兴奋型紧张症的病例报告，其诊断是根据严格标准作出的。作者报告了1例患者，在氯氮平突然停药后出现紧张性木僵状态，伴有胆碱能和血清素能亢进的特征。在重新使用氯氮平后，紧张状态在1周内得到缓解。提示血清素能亢进参与了该患者氯氮平戒断紧张综合征的发病机制，这是由胆碱能反跳所致。