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[非特异性炎症性肠病的保守治疗]

[The conservative treatment of nonspecific inflammatory bowel diseases].

作者信息

Wojtuń Stanisław, Gil Jerzy, Chojnacki Jan, Wichan Paweł

机构信息

Klinika Gastroenterologii CSK-MON WIM w Warszawie.

出版信息

Pol Merkur Lekarski. 2004;17 Suppl 1:35-9.

Abstract

The treatment of inflammatory bowel diseases includes the nutritional management, the pharmacotherapy and the surgical treatment. The main aim of treatment is to achieve the remission, to prevent a relapse and to take a decision of surgical treatment. The treatment is introduced in the relevance to the intensification of disease. To assess properly the level of the intensification of disease there is a need of deep knowledge of clinical manifestations of the disease. In the treatment the corticosteroids, 5-aminosalicylic acid (5-ASA) or immunosuppressive treatment are used. Immunosuppressive treatment is now a widely accepted standard in Crohn's disease treatment. Some cases of Crohn's disease could be treated with anti-TNFalpha antibodies that successfully treat the relapses of disease. This treatment is especially well suited to cases that are not successfully treated with the standard pharmacological treatment. The nonsurgical treatment is successful in most cases. There are no standards of treatment of microscopic colitis. We usually start the treatment with 5-ASA and an antidiarrheal agent. In case of failure of this treatment we introduce corticosteroids. In this paper authors present basic information about the current state of knowledge about inflammatory bowel diseases treatment.

摘要

炎症性肠病的治疗包括营养管理、药物治疗和手术治疗。治疗的主要目标是实现缓解、预防复发以及决定是否进行手术治疗。治疗根据疾病的严重程度进行。为了正确评估疾病的严重程度,需要深入了解疾病的临床表现。治疗中使用皮质类固醇、5-氨基水杨酸(5-ASA)或免疫抑制治疗。免疫抑制治疗现在是克罗恩病治疗中广泛接受的标准。一些克罗恩病病例可以用抗TNFα抗体治疗,该抗体能成功治疗疾病复发。这种治疗特别适用于标准药物治疗未成功的病例。大多数情况下非手术治疗是成功的。微观性结肠炎没有治疗标准。我们通常先用5-ASA和止泻剂开始治疗。如果这种治疗失败,我们会引入皮质类固醇。在本文中,作者介绍了关于炎症性肠病治疗的当前知识状态的基本信息。

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