Fahrländer H
Schweiz Med Wochenschr. 1987 Oct 17;117(42):1620-3.
Chronic inflammatory bowel diseases are probably due to stimulation of the intestinal immune system by multiple, so far unknown antigens. Chronic inflammatory bowel diseases can be contained but not healed by corticosteroids, sulfasalazine (SASP), azathioprin and metronidazol. Healing may be expected by direct pharmacological intervention in the intestinal immune system, but these are not yet available. -5-aminosalicylic acid may replace SASP in the treatment of ulcerative colitis. When administered locally 5-ASA may be effective in cases of corticosteroid-resistant distal colitis. Controlled studies are needed before the perspectives for 5-ASA in the treatment of Crohn's disease can be assessed.
慢性炎症性肠病可能是由多种目前尚不清楚的抗原刺激肠道免疫系统所致。慢性炎症性肠病可用皮质类固醇、柳氮磺胺吡啶（SASP）、硫唑嘌呤和甲硝唑控制，但无法治愈。通过对肠道免疫系统进行直接药物干预有望实现治愈，但目前尚无此类药物。5-氨基水杨酸在溃疡性结肠炎的治疗中可替代柳氮磺胺吡啶。局部给药时，5-ASA对皮质类固醇抵抗的远端结肠炎可能有效。在评估5-ASA治疗克罗恩病的前景之前，需要进行对照研究。
