[癌抗原125作为肝硬化患者腹水的标志物]

[Cancer antigen 125 as a marker of ascites in patients with liver cirrhosis].

作者信息

Jabłkowski Maciej, Białkowska Jolanta, Koktysz Robert, Bartkowiak Jacek, Stankiewicz Wanda, Dworniak Daniela

机构信息

Katreda Chorób Zakaźnych UM w Lodzi.

出版信息

Pol Merkur Lekarski. 2004;17 Suppl 1:149-52.

PMID:15603376

Abstract

Cancer antigen 125 (CA-125) is usually used to monitor the course of epithelial ovarian cancer. It has recently been reported that liver cirrhosis is associated with elevated serum CA-125, especially in the presence of ascites. The aim of the study was to evaluate CA-125 as a marker of ascites in patients with liver cirrhosis. Seventy-two (72) patients with liver cirrhosis of different aetiology were studied. Ca-125 levels were measured in stored serum collected from the patients. Ca-125 concentrations were elevated in patients with liver cirrhosis and ascites, irrespective of patients' sex and cirrhosis aetiology. CA-125 concentrations were normal in cases of liver cirrhosis without ascites. Elevated cancer antigen 125 is a sensitive marker of cirrhotic ascites. An inappropriate use of this test in cases of liver cirrhosis in females may suggest the ovarian cancer incident and lead to unnecessary surgical intervention.

摘要

癌抗原125（CA - 125）通常用于监测上皮性卵巢癌的病程。最近有报道称，肝硬化与血清CA - 125升高有关，尤其是在存在腹水的情况下。本研究的目的是评估CA - 125作为肝硬化患者腹水的标志物。对72例不同病因的肝硬化患者进行了研究。检测了从患者采集的储存血清中的Ca - 125水平。无论患者性别和肝硬化病因如何，肝硬化合并腹水患者的Ca - 125浓度均升高。无腹水的肝硬化患者CA - 125浓度正常。癌抗原125升高是肝硬化腹水的敏感标志物。在女性肝硬化病例中不恰当地使用该检测可能提示卵巢癌的发生，并导致不必要的手术干预。