Simsek H, Savas M C, Kadayifci A, Tatar G
Department of Internal Medicine, Hacettepe University Medical School, Ankara, Turkey.
Am J Gastroenterol. 1997 Jul;92(7):1174-6.
High serum cancer antigen (CA) 125 levels have been shown to be present in patients with ovarian carcinoma, nongynecological cancers, and some benign diseases and have been used as a useful marker for monitoring patients with epithelial ovarian cancer. Although tuberculous peritonitis with elevated serum CA 125 levels is an important diagnostic problem because it may lead to misdiagnosis as ovarian carcinoma and unnecessary laparatomies, the levels of CA 125 in patients with tuberculous peritonitis has not been studied in detail.
Serum CA 125 levels in 11 consecutive patients (2 males, 9 females) with tuberculous peritonitis admitted to Hacettepe University and 20 healthy adult controls (7 males, 13 females) were studied.
Serum CA 125 levels were found to be elevated in all patients with tuberculous peritonitis. The mean level in the study group was 316.6 IU/ml, whereas the level was 13.8 IU/ml in the control group (p < 0.0001). Serum CA 125 normalization showed a very close correlation with the response to antituberculous therapy.
Tuberculous peritonitis must be considered in a differential diagnosis of patients with elevated serum CA 125 concentration. Correct diagnosis may prevent unnecessary laparatomies performed under the assumption of ovarian carcinoma, because it is cured completely by antituberculous therapy. Serum CA 125 level might be used as an effective marker in the diagnosis and follow-up of patients with tuberculous peritonitis.
血清癌抗原（CA）125水平升高已被证实存在于卵巢癌、非妇科癌症及一些良性疾病患者中，并被用作监测上皮性卵巢癌患者的有用标志物。尽管血清CA 125水平升高的结核性腹膜炎是一个重要的诊断问题，因为它可能导致误诊为卵巢癌并进行不必要的剖腹手术，但结核性腹膜炎患者的CA 125水平尚未得到详细研究。
对哈杰泰佩大学收治的11例（2例男性，9例女性）结核性腹膜炎患者及20名健康成人对照者（7例男性，13例女性）的血清CA 125水平进行了研究。
所有结核性腹膜炎患者的血清CA 125水平均升高。研究组的平均水平为316.6 IU/ml，而对照组为13.8 IU/ml（p<0.0001）。血清CA 125水平恢复正常与抗结核治疗反应密切相关。
血清CA 125浓度升高的患者在鉴别诊断时必须考虑结核性腹膜炎。正确诊断可避免在假定为卵巢癌的情况下进行不必要的剖腹手术，因为结核性腹膜炎可通过抗结核治疗完全治愈。血清CA 125水平可作为结核性腹膜炎患者诊断和随访的有效标志物。
