急性前壁心肌梗死患者直接冠状动脉成形术后TIMI帧数与微血管损伤程度的关系
Relation between the TIMI frame count and the degree of microvascular injury after primary coronary angioplasty in patients with acute anterior myocardial infarction.
作者信息
Ohara Y, Hiasa Y, Takahashi T, Yamaguchi K, Ogura R, Ogata T, Yuba K, Kusunoki K, Hosokawa S, Kishi K, Ohtani R
机构信息
Division of Cardiology, Tokushima Red Cross Hospital, 28-1 Shinbiraki, Chuden-cho, Komatsushima-shi, Tokushima 773-8502, Japan.
出版信息
Heart. 2005 Jan;91(1):64-7. doi: 10.1136/hrt.2003.029892.
Abstract
OBJECTIVE
To investigate the relation between thrombolysis in myocardial infarction (TIMI) frame count (TFC) and coronary blood flow velocity (CBFV) parameters reflecting the degree of microvascular injury in patients with acute myocardial infarction.
RESULTS
TFC and CBFV were measured after primary coronary angioplasty in 103 consecutive patients with their first anterior wall acute myocardial infarction. TFC correlated inversely with the averaged peak velocity (r = -0.43, p < 0.0001). However, TFC did not correlate significantly with diastolic deceleration time and with the averaged systolic peak velocity (r = -0.16, p = 0.22, and r = -0.23, p = 0.16, respectively). The patients were divided into two groups according to presence (35 patients) or absence (68 patients) of systolic flow reversal. There was no significant difference in TFC between the two groups (29 (16) v 25 (13), p = 0.20).
CONCLUSIONS
These findings suggest that the TFC reflects epicardial CBFV. However, it is not accurate enough to assess the degree of microvascular injury after primary coronary angioplasty.
摘要
目的
探讨心肌梗死溶栓（TIMI）帧数（TFC）与反映急性心肌梗死患者微血管损伤程度的冠状动脉血流速度（CBFV）参数之间的关系。
结果
对103例首次发生前壁急性心肌梗死的连续患者行直接冠状动脉成形术后测量TFC和CBFV。TFC与平均峰值速度呈负相关（r = -0.43，p < 0.0001）。然而，TFC与舒张期减速时间及平均收缩期峰值速度无显著相关性（分别为r = -0.16，p = 0.22；r = -0.23，p = 0.16）。根据是否存在收缩期血流逆转将患者分为两组（35例存在，68例不存在）。两组间TFC无显著差异（29（16）对25（13），p = 0.20）。
结论
这些结果提示TFC反映心外膜CBFV。然而，它在评估直接冠状动脉成形术后微血管损伤程度方面不够准确。
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