使用多频电阻抗识别皮肤癌——一种潜在的筛查工具。

Skin cancer identification using multifrequency electrical impedance--a potential screening tool.

作者信息

Aberg Peter, Nicander Ingrid, Hansson Johan, Geladi Paul, Holmgren Ulf, Ollmar Stig

机构信息

Division of Medical Engineering, Karolinska Institutet, Novum Research Park, SE-14186 Huddinge, Sweden.

出版信息

IEEE Trans Biomed Eng. 2004 Dec;51(12):2097-102. doi: 10.1109/TBME.2004.836523.

DOI:10.1109/TBME.2004.836523

PMID:15605856

Abstract

Electrical bio-impedance can be used to assess skin cancers and other cutaneous lesions. The aim of this study was to distinguish skin cancer from benign nevi using multifrequency impedance spectra. Electrical impedance spectra of about 100 skin cancers and 511 benign nevi were measured. Impedance of reference skin was measured ipsi-laterally to the lesions. The impedance relation between lesion and reference skin was used to distinguish the cancers from the nevi. It was found that it is possible to separate malignant melanoma from benign nevi with 75% specificity at 100% sensitivity, and to distinguish nonmelanoma skin cancer from benign nevi with 87% specificity at 100% sensitivity. The power of skin cancer detection using electrical impedance is as good as, or better than, conventional visual screening made by general practitioners.

摘要

生物电阻抗可用于评估皮肤癌和其他皮肤病变。本研究的目的是使用多频阻抗谱区分皮肤癌和良性痣。测量了约100例皮肤癌和511例良性痣的电阻抗谱。在病变同侧测量参考皮肤的阻抗。利用病变与参考皮肤之间的阻抗关系来区分癌症和痣。结果发现，在100%灵敏度下，恶性黑色素瘤与良性痣的区分特异性可达75%，非黑色素瘤皮肤癌与良性痣的区分特异性在100%灵敏度下可达87%。利用电阻抗检测皮肤癌的能力与全科医生进行的传统视觉筛查相当，甚至更好。