白细胞介素-8、细胞间黏附分子-1和肿瘤坏死因子-α基因多态性与多系统萎缩风险

Interleukin-8, intercellular adhesion molecule-1 and tumour necrosis factor-alpha gene polymorphisms and the risk for multiple system atrophy.

作者信息

Infante Jon, Llorca Javier, Berciano José, Combarros Onofre

机构信息

Neurology Service, University Hospital Marqués de Valdecilla, University of Cantabria, 39008 Santander, Spain.

出版信息

J Neurol Sci. 2005 Jan 15;228(1):11-3. doi: 10.1016/j.jns.2004.09.023.

DOI:10.1016/j.jns.2004.09.023

PMID:15607204

Abstract

In a case-control study using a clinically well-defined group of 41 multiple system atrophy (MSA) patients and 93 control subjects, the interleukin (IL)-8 (-251) TT genotype was associated with an approximately fourfold increased risk for MSA and, furthermore, this risk increased elevenfold with the simultaneous presence of the intercellular adhesion molecule-1 (ICAM-1: E469K) KK genotype, suggesting a gene-gene interaction. These data support a role for inflammation-related genes in risk for MSA.

摘要

在一项病例对照研究中，选取了临床明确诊断的41例多系统萎缩（MSA）患者和93名对照者，白细胞介素（IL）-8（-251）TT基因型与MSA风险增加约四倍相关，此外，当同时存在细胞间黏附分子-1（ICAM-1: E469K）KK基因型时，该风险增加至十一倍，提示存在基因-基因相互作用。这些数据支持炎症相关基因在MSA风险中发挥作用。