Department of Neurology and Epileptology, Centre of Postgraduate Medical Education, Warsaw, Poland.
Department of Neurology, Medical University of Warsaw, Warsaw, Poland.
Front Immunol. 2023 Jun 22;14:1214677. doi: 10.3389/fimmu.2023.1214677. eCollection 2023.
Misfolding protein aggregation inside or outside cells is the major pathological hallmark of several neurodegenerative diseases. Among proteinopathies are neurodegenerative diseases with atypical Parkinsonism and an accumulation of insoluble fibrillary alpha-synuclein (synucleinopathies) or hyperphosphorylated tau protein fragments (tauopathies). As there are no therapies available to slow or halt the progression of these disea ses, targeting the inflammatory process is a promising approach. The inflammatory biomarkers could also help in the differential diagnosis of Parkinsonian syndromes. Here, we review inflammation's role in multiple systems atrophy pathogenesis, diagnosis, and treatment.
蛋白质在细胞内外错误折叠聚集是几种神经退行性疾病的主要病理特征。在蛋白构象病中，包括以不溶性纤维状α-突触核蛋白（α-突触核蛋白病）或过度磷酸化的tau 蛋白片段（tau 蛋白病）积累为特征的神经退行性疾病和非典型帕金森病。由于目前尚无能够减缓或阻止这些疾病进展的治疗方法，因此靶向炎症过程是一种很有前途的方法。炎症生物标志物也有助于帕金森综合征的鉴别诊断。在这里，我们综述了炎症在多系统萎缩发病机制、诊断和治疗中的作用。
