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Functional and motor response to low dose olanzapine in Huntington's disease: case report.

作者信息

Laks Jerson, Rocha Marlos, Capitão Claudia, Domingues Romeu Côrtes, Ladeia Giovanna, Lima Maurício, Engelhardt Eliasz

机构信息

Center for Alzheimer's Disease and Related Disorders, Psychiatry Institute, Federal University of Rio de Janeiro, Brazil.

出版信息

Arq Neuropsiquiatr. 2004 Dec;62(4):1092-4. doi: 10.1590/s0004-282x2004000600030. Epub 2004 Dec 15.

DOI:10.1590/s0004-282x2004000600030
PMID:15608976
Abstract

Previous reports on the use of olanzapine in Huntington's disease (HD) used doses ranging from 10-30 mg. We report a case of HD with marked delusions and behavioral impairment assessed by the Unified Huntington's Disease Rating Scale at baseline and four months later treated with a low dose of olanzapine. The patient improved in motor, psychiatric and activity of daily living symptoms after four months of treatment. The response to a low dose of olanzapine in HD may be an indicator of efficacy in similar cases. Further randomized controlled trials can properly assess these findings.

摘要

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