五例蒽环类药物所致心肌病患者经卡维地洛治疗有效。

Five cases of anthracycline-induced cardiomyopathy effectively treated with carvedilol.

作者信息

Mukai Yasushi, Yoshida Tomoki, Nakaike Ryuichi, Mukai Naoko, Iwato Koji, Kyo Taiichi, Kaseda Shunichi

机构信息

Hiroshima Red-Cross and Atomic Bomb Survivors, Hiroshima.

出版信息

Intern Med. 2004 Nov;43(11):1087-8. doi: 10.2169/internalmedicine.43.1087.

DOI:10.2169/internalmedicine.43.1087

PMID:15609710

Abstract

Anthracycline, a widely used anti-cancer agent, can elicit irreversible cardiomyopathy called anthracycline-induced cardiomyopathy (ACM). In this report, we describe 5 cases of severe chronic heart failure due to ACM effectively treated with the beta-blocker, carvedilol. Their left ventricular function as well as cardiac symptoms were persistently improved after treatment with carvedilol, suggesting that carvedilol may be an effective therapeutic strategy for ACM as demonstrated in other forms of chronic heart failure.

摘要

蒽环类药物是一种广泛使用的抗癌药物，可引发不可逆的心肌病，称为蒽环类药物诱导的心肌病（ACM）。在本报告中，我们描述了5例因ACM导致的严重慢性心力衰竭患者，使用β受体阻滞剂卡维地洛进行有效治疗的情况。在用卡维地洛治疗后，他们的左心室功能以及心脏症状持续改善，这表明卡维地洛可能是治疗ACM的一种有效策略，正如在其他形式的慢性心力衰竭中所证明的那样。