Kim Stella K, Chan Chi-Chao, Wallace Dana J
University of Texas, M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, #443, Houston, TX 77030, USA.
Curr Oncol Rep. 2005 Jan;7(1):74-9. doi: 10.1007/s11912-005-0029-6.
Primary intraocular lymphoma (PIOL) is a subset of primary central nervous system lymphoma (PCNSL) in which malignant lymphoid cells invade the retina, vitreous body, or optic nerve head. It is usually a large B-cell non-Hodgkin's lymphoma. PIOL typically presents as a vitritis that is unresponsive to corticosteroid therapy. Diagnosis of PIOL requires pathologic confirmation of malignant cells in specimens of the cerebrospinal fluid, vitreous, or chorioretinal biopsies. The optimal therapy for PIOL has yet to be determined. It is generally believed that PIOL should be treated with a combination of systemic chemotherapy, including high-dose methotrexate and radiotherapy. However, several new developments for PIOL with central nervous system involvement have been reported, including intrathecal therapy and autologous stem-cell transplantation. In addition, intravitreal methotrexate has been successful in the treatment of isolated recurrent ocular disease. This article provides an overview of treatment modalities for initial, recurrent, and relapsed PIOL.
原发性眼内淋巴瘤（PIOL）是原发性中枢神经系统淋巴瘤（PCNSL）的一个亚型，其中恶性淋巴细胞侵犯视网膜、玻璃体或视神经乳头。它通常是一种大B细胞非霍奇金淋巴瘤。PIOL通常表现为对皮质类固醇治疗无反应的葡萄膜炎。PIOL的诊断需要脑脊液、玻璃体或脉络膜视网膜活检标本中恶性细胞的病理证实。PIOL的最佳治疗方案尚未确定。一般认为，PIOL应采用全身化疗联合治疗，包括大剂量甲氨蝶呤和放疗。然而，已有报道称PIOL合并中枢神经系统受累有一些新进展，包括鞘内治疗和自体干细胞移植。此外，玻璃体内注射甲氨蝶呤已成功用于治疗孤立性复发性眼部疾病。本文概述了初发、复发和难治性PIOL的治疗方式。
