Choi John Y, Kafkala Chrysanthi, Foster C Stephen
Retina Specialists of Boston, Cambridge, MA, USA.
Semin Ophthalmol. 2006 Jul-Sep;21(3):125-33. doi: 10.1080/08820530500350498.
Primary intraocular lymphoma (PIOL) is a type of primary central nervous system lymphoma (PCNSL). It is the most common neoplastic masquerade syndrome involving the eye. Its protean ocular manifestations, plus in many cases the initial positive response to corticosteroid therapy for presumed uveitis, delay accurate diagnosis. A high index of suspicion is essential, followed by tissue biopsy with cytology and ancillary studies. Current treatment is based on chemotherapy featuring high-dose methotrexate and radiation therapy. Prognosis is poor due to CNS involvement, but newer therapies have had some success in prolonging survival.
原发性眼内淋巴瘤（PIOL）是原发性中枢神经系统淋巴瘤（PCNSL）的一种类型。它是累及眼部最常见的肿瘤伪装综合征。其多样的眼部表现，加上在许多病例中对疑似葡萄膜炎进行皮质类固醇治疗初期的阳性反应，延误了准确诊断。高度的怀疑指数至关重要，随后进行组织活检及细胞学和辅助检查。目前的治疗基于以大剂量甲氨蝶呤为特征的化疗和放射治疗。由于中枢神经系统受累，预后较差，但新的治疗方法在延长生存期方面已取得了一些成功。
