来自软珊瑚树状肾形珊瑚属物种的类固醇

Steroids from the soft coral Dendronephthya sp.

作者信息

Li Guoqiang, Deng Zhiwei, Guan Huashi, van Ofwegen Leen, Proksch Peter, Lin Wenhan

机构信息

State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, China.

出版信息

Steroids. 2005 Jan;70(1):13-8. doi: 10.1016/j.steroids.2004.09.003. Epub 2004 Dec 8.

DOI:10.1016/j.steroids.2004.09.003

PMID:15610892

Abstract

Fifteen steroids were isolated from the soft coral Dendronephthya sp., of which five are determined as new compounds, namely (22E)-3-O-beta-formylcholest-5,22-diene (1), (22E)-3-O-beta-formyl-24-methyl-cholest-5,22-diene (2), 2-ethoxycarbonyl-2-beta-hydroxy-A-nor-cholest-5-ene-4-one (3), (22E)-2-ethoxycarbonyl-2-beta-hydroxy-A-nor-cholest-5,22-diene-4-one (4), and (22E)-2-ethoxycarbonyl-2-beta-hydroxy-24-mthyl-A-nor-cholest-5,22-diene-4- one (5). 1 and 2 belonged to 3-O-formylated cholesterol analogues, and 3 to 5 are unique ring A-contracted steroids. Their structures were elucidated by extensive 2D NMR in association with IR, MS analysis.

摘要

从软珊瑚Dendronephthya sp.中分离出15种甾体化合物，其中5种被确定为新化合物，即(22E)-3-O-β-甲酰基胆甾-5,22-二烯(1)、(22E)-3-O-β-甲酰基-24-甲基胆甾-5,22-二烯(2)、2-乙氧羰基-2-β-羟基-A-降胆甾-5-烯-4-酮(3)、(22E)-2-乙氧羰基-2-β-羟基-A-降胆甾-5,22-二烯-4-酮(4)和(22E)-2-乙氧羰基-2-β-羟基-24-甲基-A-降胆甾-5,22-二烯-4-酮(5)。1和2属于3-O-甲酰化胆固醇类似物，3至5是独特的A环缩合甾体。通过广泛的二维核磁共振结合红外光谱、质谱分析确定了它们的结构。