来自中国软珊瑚肾形海鳃属物种的新型4α-甲基甾体

New 4alpha-methyl steroids from a Chinese soft coral Nephthea sp.

作者信息

Ma Ke, Li Wei, Fu Hongwei, Koike Kazuo, Lin Wenhan, van Ofwegen Leen, Fu Hongzheng

机构信息

State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing, China.

出版信息

Steroids. 2007 Dec;72(14):901-7. doi: 10.1016/j.steroids.2007.07.006. Epub 2007 Jul 17.

DOI:10.1016/j.steroids.2007.07.006

PMID:17881025

Abstract

Three new 4alpha-methyl steroids, 4alpha-methyl-ergost-7,24(28)-diene-3beta-ol-23-one (1), 4alpha-methyl-ergost-8(14),24(28)-diene-3beta-ol-23-one (2), 4alpha-methyl-ergost-24(28)-en-3beta,11beta-diol-23-one (3), and two new polyoxygenated steroids, ergost-5,25-diene-3beta,24S,28-triol (4), ergost-5,24(28)-diene-3beta,23S-diol (5), along with one known steroid 24-methylencholesterol (6) were isolated from the soft coral Nephthea sp. Their structures including the relative configurations were elucidated by extensive 1D and 2D NMR spectra analysis. The absolute configurations of (4) and (5) were determined by the Mosher's method.

摘要

从软珊瑚Nephthea sp.中分离出三种新的4α-甲基甾体，即4α-甲基-麦角甾-7,24(28)-二烯-3β-醇-23-酮（1）、4α-甲基-麦角甾-8(14),24(28)-二烯-3β-醇-23-酮（2）、4α-甲基-麦角甾-24(28)-烯-3β,11β-二醇-23-酮（3），以及两种新的多氧化甾体，即麦角甾-5,25-二烯-3β,24S,28-三醇（4）、麦角甾-5,24(28)-二烯-3β,23S-二醇（5），还有一种已知甾体24-亚甲基胆固醇（6）。通过广泛的一维和二维核磁共振光谱分析阐明了它们的结构，包括相对构型。（4）和（5）的绝对构型通过莫舍尔法确定。