Roelants G E, Pearson T W, Tyrer H W, Mayor-Withey K S, Lundin L B
Eur J Immunol. 1979 Mar;9(3):195-9. doi: 10.1002/eji.1830090305.
Spleen cells from Trypanosoma congolense-infected mice showed a drastic depression in their capacity to respond to B and T lymphocyte mitogens and to allogeneic spleen cells in mixed lymphocyte cultures. Spleen cells from infected mice were also poor stimulators in mixed lymphocyte cultures. The poor responsiveness or stimulation capacity was not due simply to dilution of relevant B or T lymphocytes by the large number of null cells found in the spleens of infected animals. These null cells expressed approximately eight times more H-2 antigen than spleen cells from normal (uninfected) mice and were devoid of Ia antigens.
来自感染刚果锥虫小鼠的脾细胞，在对B和T淋巴细胞有丝分裂原以及在混合淋巴细胞培养中对同种异体脾细胞的反应能力方面表现出显著下降。来自感染小鼠的脾细胞在混合淋巴细胞培养中也是较差的刺激细胞。反应性或刺激能力差并非仅仅是由于感染动物脾脏中大量无活性细胞稀释了相关的B或T淋巴细胞所致。这些无活性细胞表达的H-2抗原比正常（未感染）小鼠的脾细胞多约八倍，且缺乏Ia抗原。
