Hirokawa K, Eishi Y, Albright J W, Albright J F
Infect Immun. 1981 Dec;34(3):1008-17. doi: 10.1128/iai.34.3.1008-1017.1981.
Mice infected with Trypanosoma musculi developed hyperplasia of the spleen, lymph nodes, and liver; in contrast, their thymuses displayed transient involution. All organs returned to normal in a month or less. There was modest anemia, lasting until the parasites were cleared from the bloodstream, followed by a rapid influx of erythrocytes into the blood and a subsequent return to normal erythrocyte numbers. During the first 2 weeks, trypanosomes and trypanosome-derived substances were found in the livers and, in moderate amounts, in the red pulp of the spleens; thereafter, trypanosomes and trypanosome-derived substances gradually decreased in these organs. The lymphoreticular hyperplasia involved a large increase of immunoglobulin G (IgG)-containing cells in the spleens and lymph nodes at 2 weeks of infection. Hyperplasia of immunoglobulin-producing cells correlated with elevation of serum immunoglobulins, especially IgG. Cells producing IgG in the spleens proliferated mainly around the central arterioles of the white pulp, i.e., in the T-cell-dependent areas. The decline of trypanosome-derived substances in the livers and spleens was associated with marked hyperplasia of IgG-containing cells in the spleens and lymph nodes. These results suggest that trypanosome-mediated depression of murine immune responses is attributable to proliferation and terminal differentiation of more-mature lymphoid cells and temporary inhibition of normal maturation of less-mature precursor cells.
感染鼠锥虫的小鼠出现脾脏、淋巴结和肝脏增生；相反，它们的胸腺表现出短暂萎缩。所有器官在一个月或更短时间内恢复正常。出现轻度贫血，持续到寄生虫从血液中清除，随后红细胞迅速涌入血液，红细胞数量随后恢复正常。在最初的2周内，在肝脏中发现了锥虫和锥虫衍生物质，在脾脏红髓中也发现了适量的此类物质；此后，这些器官中的锥虫和锥虫衍生物质逐渐减少。感染2周时，脾和淋巴结中的免疫球蛋白G（IgG）细胞大量增加，出现淋巴网状组织增生。产生免疫球蛋白的细胞增生与血清免疫球蛋白尤其是IgG升高相关。脾脏中产生IgG的细胞主要在白髓中央小动脉周围增殖，即在T细胞依赖区增殖。肝脏和脾脏中锥虫衍生物质的减少与脾脏和淋巴结中含IgG细胞的明显增生有关。这些结果表明，锥虫介导的小鼠免疫反应抑制归因于更成熟淋巴细胞的增殖和终末分化以及较不成熟前体细胞正常成熟的暂时抑制。
