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1
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Clin Exp Immunol. 1982 Jun;48(3):633-40.
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A follow up of T-cell subsets and of anti-M. leprae antibody titer as measured by the FLA-ABS test in Melanesian leprosy patients under polychemotherapy.对接受多药化疗的美拉尼西亚麻风患者，通过荧光麻风抗体吸收试验（FLA-ABS）测定其T细胞亚群和抗麻风杆菌抗体滴度的随访研究。
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引用本文的文献

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2
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J Exp Med. 1989 May 1;169(5):1565-81. doi: 10.1084/jem.169.5.1565.
3
Epidermal keratinocyte Ia expression, Langerhans cell hyperplasia and lymphocytic infiltration in skin lesions of leprosy.麻风病皮肤损害中表皮角质形成细胞Ia表达、朗格汉斯细胞增生及淋巴细胞浸润
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4
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5
Tumor necrosis factor production in patients with leprosy.麻风病患者体内肿瘤坏死因子的产生
Infect Immun. 1992 Apr;60(4):1441-6. doi: 10.1128/iai.60.4.1441-1446.1992.
6
T cell and cytokine patterns in leprosy skin lesions.麻风皮肤病变中的T细胞和细胞因子模式。
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本文引用的文献

1
Variations in dinitrochlorobenzene responsivity in untreated leprosy: evidence of a beneficial role for anergy.未经治疗的麻风病患者对二硝基氯苯反应性的差异：无反应性起有益作用的证据。
Int J Lepr Other Mycobact Dis. 1980 Jun;48(2):120-5.
2
Studies on T cell subsets and functions in leprosy.麻风病中T细胞亚群及功能的研究。
Clin Exp Immunol. 1981 Jun;44(3):491-500.
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Classification of leprosy according to immunity. A five-group system.根据免疫情况对麻风病进行分类。一种五组分类系统。
Int J Lepr Other Mycobact Dis. 1966 Jul-Sep;34(3):255-73.
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Immunologic suppression in leprosy and its relation to lepromatous disease.
Int J Lepr Other Mycobact Dis. 1968 Jan-Mar;36(1):87-90.
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[Study ofn leprosy immunity].
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Phytohaemagglutinin-induced lymphocyte transformation in leprosy.植物血凝素诱导的麻风病淋巴细胞转化
Clin Exp Immunol. 1971 Jul;9(1):33-43.
7
Significance of variations within the lepromatous group.瘤型组内变异的意义。
Lepr Rev. 1969 Jul;40(3):143-52. doi: 10.5935/0305-7518.19690026.
8
Some considerations regarding the immunology of leprosy.
Int J Lepr Other Mycobact Dis. 1971 Apr-Jun;39(2):556-64.
9
Production of macrophage inhibitory factor by patients with leprosy.麻风病患者巨噬细胞抑制因子的产生
Arch Dermatol. 1971 Apr;103(4):358-61.
10
Studies of immune mechanisms in leprosy. 3. The role of cellular and humoral factors in impairment of the in vitro immune response.麻风病免疫机制研究。3. 细胞和体液因素在体外免疫反应受损中的作用。
J Immunol. 1971 Apr;106(4):888-99.

瘤型麻风病中细胞毒性T细胞生成缺陷。

Defect in the generation of cytotoxic T cells in lepromatous leprosy.

作者信息

Stach J L, Strobel M, Fumoux F, Bach J F

出版信息

Clin Exp Immunol. 1982 Jun;48(3):633-40.

PMID:6214342
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1536602/
Abstract

Cytotoxic T cells are consistently produced in normal individuals after in vitro stimulation by a pool of mitomycin-treated normal lymphocytes. Patients suffering from lepromatous leprosy (LL), presenting with large amounts of Mycobacterium leprae and without a history of erythema nodosum leprosum (ENL) are unable to generate such cytotoxic T cells, while lepromatous patients with ENL which, in the present study were all deprived of M. leprae, react normally.

摘要

在体外经丝裂霉素处理的正常淋巴细胞池刺激后，正常个体中持续产生细胞毒性T细胞。患有瘤型麻风（LL）的患者，体内存在大量麻风分枝杆菌且无麻风结节性红斑（ENL）病史，无法产生此类细胞毒性T细胞，而在本研究中所有麻风杆菌均已清除的有ENL的瘤型患者则反应正常。