瘤型麻风病中细胞毒性T细胞生成缺陷。
Defect in the generation of cytotoxic T cells in lepromatous leprosy.
作者信息
Stach J L, Strobel M, Fumoux F, Bach J F
出版信息
Clin Exp Immunol. 1982 Jun;48(3):633-40.
Abstract
Cytotoxic T cells are consistently produced in normal individuals after in vitro stimulation by a pool of mitomycin-treated normal lymphocytes. Patients suffering from lepromatous leprosy (LL), presenting with large amounts of Mycobacterium leprae and without a history of erythema nodosum leprosum (ENL) are unable to generate such cytotoxic T cells, while lepromatous patients with ENL which, in the present study were all deprived of M. leprae, react normally.
摘要
在体外经丝裂霉素处理的正常淋巴细胞池刺激后，正常个体中持续产生细胞毒性T细胞。患有瘤型麻风（LL）的患者，体内存在大量麻风分枝杆菌且无麻风结节性红斑（ENL）病史，无法产生此类细胞毒性T细胞，而在本研究中所有麻风杆菌均已清除的有ENL的瘤型患者则反应正常。
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