Boden Guenther
Division of Endocrinology/Diabetes/Metabolism, Temple University School of Medicine, Philadelphia, PA 19140, USA.
J Investig Med. 2004 Sep;52(6):375-8. doi: 10.1136/jim-52-06-31.
Reviewed are data on gluconeogenesis (GNG) and glycogenolysis (GL) obtained in healthy volunteers and diabetic patients with newer, quantitative methods. Specifically addressed are effects of overnight and prolonged fasting, of acute changes in serum insulin and plasma free fatty acid (FFA) levels, as well as acute changes of combined FFA and insulin levels on GNG and GL in nondiabetic subjects and of abnormalities in GNG and GL in patients with type 1 and type 2 diabetes.
本文回顾了采用更新的定量方法在健康志愿者和糖尿病患者中获得的有关糖异生（GNG）和糖原分解（GL）的数据。具体讨论了过夜禁食和长期禁食、血清胰岛素和血浆游离脂肪酸（FFA）水平的急性变化，以及非糖尿病受试者中FFA和胰岛素水平联合急性变化对GNG和GL的影响，以及1型和2型糖尿病患者GNG和GL的异常情况。
