Kim S W, Dysken M W, Kuskowski M
Department of Psychiatry, Hennepin County Medical Center, Minneapolis, MN 55415.
Psychiatry Res. 1992 Jan;41(1):37-44. doi: 10.1016/0165-1781(92)90016-v.
Twenty-three nondepressed patients with DSM-III obsessive-compulsive disorder completed the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), the Symptom Checklist-90 (SCL-90), and the National Institute of Mental Health Global Obsessive-Compulsive Scale (NIMH-GOCS) once a week for a total of three times during a 2-week medication-free period and 10 times during a 10-week double-blind drug treatment period. The pretreatment test-retest reliabilities were determined for the Y-BOCS, NIMH-GOCS, and the SCL-90-Obsessive-Compulsive Subscale (SCL-90-OCS). Comparisons of the three instruments revealed that the Y-BOCS and the NIMH-GOCS were significantly more reliable than the SCL-90-OCS. Posttreatment correlations were obtained between change scores on the Y-BOCS and NIMH-GOCS and the SCL-90-OCS. Correlations were high and statistically significant for both the Y-BOCS and the NIMH-GOCS, but the correlations of the SCL-90-OCS with the Y-BOCS, NIMH-GOCS, Physician's Global Rating, and the Patient's Global Rating were poor. The findings suggest that the SCL-90-OCS may not be a sensitive instrument in assessing change in obsessive-compulsive symptoms.
23名符合《精神疾病诊断与统计手册》第三版（DSM-III）强迫症诊断标准的非抑郁症患者，在为期2周的无药物治疗期内，每周完成一次耶鲁-布朗强迫症量表（Y-BOCS）、症状自评量表90（SCL-90）和美国国立精神卫生研究所总体强迫症量表（NIMH-GOCS），共进行3次；在为期10周的双盲药物治疗期内，每周完成一次，共进行10次。测定了Y-BOCS、NIMH-GOCS和SCL-90强迫症分量表（SCL-90-OCS）治疗前的重测信度。对这三种测评工具的比较显示，Y-BOCS和NIMH-GOCS比SCL-90-OCS的信度显著更高。获得了Y-BOCS和NIMH-GOCS的变化分数与SCL-90-OCS之间的治疗后相关性。Y-BOCS和NIMH-GOCS的相关性都很高且具有统计学意义，但SCL-90-OCS与Y-BOCS、NIMH-GOCS、医生总体评定以及患者总体评定之间的相关性较差。研究结果表明，SCL-90-OCS在评估强迫症症状变化方面可能不是一个敏感的测评工具。
