Ralph Stuart A
Institut Pasteur, Biology of Host-Parasite Interactions Unit (CNRS URA2581) 25, rue du Docteur Roux, F-75724 PARIS CEDEX 15, France.
Mol Microbiol. 2005 Jan;55(1):1-4. doi: 10.1111/j.1365-2958.2004.04314.x.
Our understanding of the Plasmodium mitochondrion and apicoplast has been greatly assisted by the genome sequence project. Sequence data have seeded recent research showing that the apicoplast is the site of several anabolic pathways including fatty acid synthesis. The discovery of an active apicoplast pyruvate dehydrogenase complex implies this enzyme generates the acetyl-CoA needed for fatty acid synthesis. However, the absence of a corresponding mitochondrial complex suggests that energy generation in Plasmodium is considerably different from pathways described in other eukaryotes.
疟原虫线粒体和顶质体的基因组序列项目极大地推动了我们对它们的认识。序列数据为近期的研究提供了基础，这些研究表明顶质体是包括脂肪酸合成在内的多种合成代谢途径的场所。活跃的顶质体丙酮酸脱氢酶复合体的发现意味着该酶产生了脂肪酸合成所需的乙酰辅酶A。然而，相应线粒体复合体的缺失表明疟原虫中的能量产生与其他真核生物中描述的途径有很大不同。
