Cohan S L, Redmond D, Chen M
Department of Neurology, Georgetown University School of Medicine, Washington, DC.
Stroke. 1992 Feb;23(2):229-33. doi: 10.1161/01.str.23.2.229.
This study was designed to determine whether flunarizine enhances the rate of brain recovery as measured by electroencephalography after cerebral ischemia and whether these effects are attributable to changes in brain temperature.
Male gerbils (n = 81) were treated with either 10 mg/kg flunarizine or its vehicle, beta-cyclodextrin, intraperitoneally, 60 minutes before bilateral carotid occlusion of either 4 or 6 minutes' duration. The electroencephalogram was continuously recorded in the preischemic, ischemic, and postischemic stages of the experiment and rated for the time necessary for the return of 4-6, 7-10, and 11-15 Hz activity. In a second set of experiments, intracerebral temperature was monitored for 60 minutes before ischemia, during 10 minutes of carotid occlusion, and for 60 minutes after ischemia.
Flunarizine pretreatment resulted in significantly more rapid return of electroencephalographic activity in each of the three frequency categories monitored when compared with those animals pretreated with vehicle alone (p less than 0.001). Flunarizine had no effect on brain temperature before, during, or up to 60 minutes after termination of ischemia.
Flunarizine, which has been of efficacy in reducing neuronal death, mortality, and functional impairment when administered after ischemic insults, may have prophylactic value in accelerating brain recovery from ischemia, but does not have this effect as a result of altered brain temperature.
本研究旨在确定氟桂利嗪是否能提高脑缺血后通过脑电图测量的脑恢复率，以及这些作用是否归因于脑温度的变化。
81只雄性沙鼠在双侧颈动脉闭塞4分钟或6分钟前60分钟，腹腔注射10mg/kg氟桂利嗪或其溶媒β-环糊精。在实验的缺血前、缺血和缺血后阶段连续记录脑电图，并对4-6Hz、7-10Hz和11-15Hz活动恢复所需时间进行评分。在第二组实验中，在缺血前60分钟、颈动脉闭塞10分钟期间和缺血后60分钟监测脑内温度。
与仅用溶媒预处理的动物相比，氟桂利嗪预处理导致在监测的三个频率类别中脑电图活动恢复明显更快（p<0.001）。氟桂利嗪在缺血前、缺血期间或缺血终止后60分钟内对脑温度均无影响。
氟桂利嗪在缺血性损伤后给药时，在减少神经元死亡、死亡率和功能损害方面具有疗效，可能在加速脑缺血恢复方面具有预防价值，但并非由于脑温度改变而产生这种作用。
