Harris E N
Department of Medicine, University of Louisville, KY 40292.
Stroke. 1992 Feb;23(2 Suppl):I3-6.
Antiphospholipid antibodies are heterogeneous. A subset of these antibodies is associated with arterial and venous thrombosis and recurrent pregnancy loss. This subset is best diagnosed by the lupus anticoagulant and solid-phase anticardiolipin tests. Solid-phase anticardiolipin tests use an enzyme-linked immunosorbent assay employing cardiolipin or other negatively charged phospholipids as the antigen. Patients with antiphospholipid antibodies who have experienced thrombotic disorders often have an IgG isotype, persistent at high levels for prolonged periods. The anticardiolipin test has been standardized so that antibody isotype and level can be determined reproducibly. Standardized serological tests to measure antiphospholipid antibodies will enable uniform identification of patients at risk for thrombosis and will help elucidate the origin and mechanisms of action of these antibodies.
抗磷脂抗体具有异质性。这些抗体中的一部分与动脉和静脉血栓形成以及复发性流产有关。这一部分抗体最好通过狼疮抗凝物和固相抗心磷脂检测来诊断。固相抗心磷脂检测采用酶联免疫吸附测定法，以心磷脂或其他带负电荷的磷脂作为抗原。经历过血栓形成疾病的抗磷脂抗体患者通常具有IgG同种型，且长时间持续处于高水平。抗心磷脂检测已经标准化，因此可以可重复地确定抗体同种型和水平。用于检测抗磷脂抗体的标准化血清学检测将能够统一识别有血栓形成风险的患者，并有助于阐明这些抗体的起源和作用机制。
