Almenar Bonet Luis
Sección de Insuficiencia Cardíaca, Trasplante Cardíaco y Otras Alternativas Terapéuticas de la Sociedad Española de Cardiología, Madrid, Spain.
Rev Esp Cardiol. 2004 Dec;57(12):1197-204.
This paper outlines the general characteristics and results obtained with heart transplantation in Spain after including the data for the year 2003. In 2003, 290 heart transplants were performed. Since 1984, a total of 4386 procedures have been performed. The average clinical profile of patients receiving a heart transplant in Spain is that of a man about 50 years old, blood group A, with nonrevascularizable coronary artery disease and functional status IV/IV (NYHA). The percentage of emergency heart transplantations was 29%, which is higher than in the previous year (26%) and the mean for the preceding 5 years (20%). The early mortality rate was 13%, which is similar to the mean for the preceding 5 years (13%). After combining the 2003 results with those of the previous years, the probability of survival at 1, 5 and 10 years was 76%, 66% and 54%, respectively. When survival rates for separate periods were considered, a significant improvement was seen in the last 5 years, with survival rates at of 81% at 1 year and 74% at 5 years. The most frequent causes of death were acute graft failure in the first month, infection and rejection in the first year, and a combination of vascular disease of the graft with sudden death in the long term. Comparative analysis of survival rates shows that our long-term results are slightly better than those published in the literature, with a gradual tendency for survival rate to improve in recent years.
本文概述了纳入2003年数据后西班牙心脏移植的总体特征和成果。2003年共进行了290例心脏移植手术。自1984年以来,总共进行了4386例手术。在西班牙接受心脏移植患者的平均临床情况为:一名50岁左右的男性,A型血,患有不可行血运重建的冠状动脉疾病,心功能分级为IV/IV级(纽约心脏协会分级)。急诊心脏移植的比例为29%,高于上一年(26%)以及此前5年的平均水平(20%)。早期死亡率为13%,与此前5年的平均水平(13%)相似。将2003年的结果与前几年的结果合并后,1年、5年和10年的生存率分别为76%、66%和54%。当考虑不同时间段的生存率时,发现过去5年有显著改善,1年生存率为81%,5年生存率为74%。最常见的死亡原因是第一个月的急性移植物功能衰竭、第一年的感染和排斥反应,以及长期的移植物血管疾病合并猝死。生存率的比较分析表明,我们的长期结果略优于文献中发表的结果,且近年来生存率有逐渐提高的趋势。