Tatemichi Masayuki, Sawa Tomohiro, Gilibert Isabelle, Tazawa Hiroshi, Katoh Takahiko, Ohshima Hiroshi
International Agency for Research on Cancer, 150 Cours Albert Thomas, F 69372 Lyon Cedex 08, France.
Cancer Lett. 2005 Jan 20;217(2):197-202. doi: 10.1016/j.canlet.2004.09.002.
Tandem repeat number polymorphism of a CCTTT pentanucleotide in the promoter region of the inducible nitric oxide synthase gene (iNOS) and a polymorphism of the interleukin-1beta (IL-1B) promoter at position -31 were analyzed in DNA samples from 181 Japanese control subjects and 158 gastric cancer patients, including 96 intestinal type and 62 diffuse type. An association between the intestinal type of gastric adenocarcinoma and higher promoter activity of the iNOS gene was found in women, especially those having higher promoter activity of the IL-1B gene and without a history of smoking. Our results imply that chronic inflammation caused by excess nitric oxide generated by iNOS contributes to Helicobacter pylori-induced gastric cancer.
在181名日本对照受试者和158名胃癌患者（包括96例肠型和62例弥漫型）的DNA样本中，分析了诱导型一氧化氮合酶基因（iNOS）启动子区域CCTTT五核苷酸的串联重复数多态性以及白细胞介素-1β（IL-1B）启动子在-31位的多态性。在女性中发现肠型胃腺癌与iNOS基因较高的启动子活性之间存在关联，尤其是那些IL-1B基因启动子活性较高且无吸烟史的女性。我们的结果表明，iNOS产生的过量一氧化氮引起的慢性炎症促成了幽门螺杆菌诱导的胃癌。
