Grapin-Botton Anne
Swiss Institute for Experimental Cancer Research (ISREC), Chemin des Boveresses 155, Case Postale, CH-1066 Epalinges s/Lausanne, Switzerland.
Int J Biochem Cell Biol. 2005 Mar;37(3):504-10. doi: 10.1016/j.biocel.2004.07.010.
Ductal cells of the pancreas form the epithelial lining of the branched tubes that deliver enzymes produced by pancreatic acinar cells into the duodenum. In addition, these cells secrete bicarbonate that neutralizes stomach acidity. During development, epithelium of endodermal origin evaginates from the future duodenum area and invades the mesenchyme to form a complex branched network. All endocrine, acinar and ductal cells arise from common precursors in this epithelial structure. Adult ductal cells share some similarities with embryonic primitive ducts and may retain the ability to generate endocrine cells in the adult. Based on challenged pancreas regeneration experiments, the adult ductal cells have been proposed to be pancreatic stem cells but their role in normal endocrine cell turnover has recently been challenged. Manipulating their ability to give rise to endocrine cells may open new avenues in the treatment of diabetes and therefore they have recently been under scrutiny. In addition, in the main form of pancreatic cancer, pancreas adenocarcinoma, tumor cells share similarities with ductal cells. The secrets of an appropriate therapy for this deadly cancer may thus reside in the biology of ductal cells.
胰腺导管细胞构成分支管道的上皮内衬，这些管道将胰腺腺泡细胞产生的酶输送到十二指肠。此外，这些细胞分泌碳酸氢盐以中和胃酸。在发育过程中，内胚层来源的上皮从未来的十二指肠区域向外突出并侵入间充质，形成复杂的分支网络。所有内分泌细胞、腺泡细胞和导管细胞都起源于这个上皮结构中的共同前体。成年导管细胞与胚胎原始导管有一些相似之处，并且在成年期可能保留产生内分泌细胞的能力。基于挑战性的胰腺再生实验，成年导管细胞被认为是胰腺干细胞，但它们在正常内分泌细胞更新中的作用最近受到了挑战。操纵它们产生内分泌细胞的能力可能会为糖尿病治疗开辟新途径，因此它们最近受到了密切关注。此外，在胰腺癌的主要形式胰腺腺癌中，肿瘤细胞与导管细胞有相似之处。因此，针对这种致命癌症的适当治疗方法的奥秘可能在于导管细胞的生物学特性。
