Tam W-K, Chan H, Brown B, Leung K-W, Woo V, Yap M
Department of Optometry and Radiography, The Hong Kong Polytechnic University, Hong Kong.
Eye (Lond). 2006 Jan;20(1):18-24. doi: 10.1038/sj.eye.6701777.
To study the effect of aging retina on the multifocal electroretinogram (mfERG).
A total of 18 young subjects (age 18-24 years) and 36 elderly subjects (aged 60-85 years) with intraocular lenses (IOLs) were recruited for this study. No subjects had significant eye diseases or media opacities. mfERG was measured in standard conditions using the VERIS system (version 4.1). There were three groups of 18 subjects: (1) 18-25 years, (2) 60-70 years, and (3) 75-85 years. mfERG responses were grouped into central, paracentral, and peripheral regions for analysis. The N1 amplitude, P1 amplitude, N1 latency, and P1 latency of the first-order responses were analysed.
Age had no effect on P1 latency, N1 amplitude, and P1 amplitude; however, N1 latencies from central to peripheral regions were significantly longer for group 3 than for group 1.
This study suggests that measured age-related decreases in mfERG responses are due to optical factors (decrease in retinal light levels, scatter) before the age of 70 years, but neural factors significantly affect mfERG topography after the age of 70 years.
研究衰老视网膜对多焦视网膜电图（mfERG）的影响。
本研究招募了18名年轻受试者（年龄18 - 24岁）和36名植入人工晶状体（IOL）的老年受试者（年龄60 - 85岁）。所有受试者均无明显眼部疾病或介质混浊。使用VERIS系统（版本4.1）在标准条件下测量mfERG。18名受试者分为三组：（1）18 - 25岁，（2）60 - 70岁，（3）75 - 85岁。mfERG反应分为中央、旁中央和周边区域进行分析。分析了一阶反应的N1振幅、P1振幅、N1潜伏期和P1潜伏期。
年龄对P1潜伏期、N1振幅和P1振幅无影响；然而，第3组从中央到周边区域的N1潜伏期明显长于第1组。
本研究表明，70岁之前，mfERG反应中与年龄相关的测量值下降是由于光学因素（视网膜光水平降低、散射）所致，但70岁之后神经因素对mfERG地形图有显著影响。
Zotero 插件