Vision Research Foundation, Chennai, India.
NIHR Moorfields Biomedical Research Centre, London, UK.
Sci Rep. 2022 Jul 6;12(1):11422. doi: 10.1038/s41598-022-15425-x.
To examine the retinal structure and function in relation to diabetes duration and glycemia in patients without diabetic retinopathy (DR). 85 adults with type 2 diabetes without DR or macular edema underwent dilated indirect ophthalmoscopy, optical coherence tomography (OCT), ultra-wide field fundus photography, multifocal electroretinography (mfERG) and HbA assessment. Patients were stratified as those with diabetes duration < 10 years and ≥ 10 years. Right eyes of all participants were analyzed. mfERG was analysed as ring 12, 34, 56. No significant differences were noted in OCT-derived retinal thickness measures between groups. mfERG P1 latencies were delayed, and amplitudes (nV/deg) were reduced in all three rings in those with diabetes duration ≥ 10 years vs. < 10 years, with significant correlations to diabetes duration in all rings. Logistic regression showed that duration of diabetes ≥ 10 years was associated with greater age (odds ratio (OR) 1.081, 95% CI 1.022, 1.143) and lower P1 amplitudes in the middle ring (OR 0.924, 95% CI 0.854, 0.999). No significant correlations were observed between HbA and retinal measures. In the absence of DR, early retinal functional alterations are detectable on mfERG in patients with longer diabetes duration, but with no difference in OCT-derived retinal thickness.
检查无糖尿病视网膜病变 (DR) 的患者的糖尿病病程和血糖与视网膜结构和功能的关系。85 例无 DR 或黄斑水肿的 2 型糖尿病成人患者接受了散瞳间接检眼镜、光学相干断层扫描 (OCT)、超广角眼底照相、多焦视网膜电图 (mfERG) 和 HbA 评估。患者分为糖尿病病程<10 年和≥10 年。所有参与者的右眼均进行了分析。mfERG 分析了环 12、34、56。组间 OCT 测量的视网膜厚度无显著差异。与糖尿病病程<10 年相比，糖尿病病程≥10 年的患者 mfERG P1 潜伏期延长，所有三个环的振幅（nV/deg）降低，所有环均与糖尿病病程呈显著相关。逻辑回归显示，糖尿病病程≥10 年与年龄较大（优势比 (OR) 1.081，95%CI 1.022，1.143）和中环 P1 振幅降低有关（OR 0.924，95%CI 0.854，0.999）。HbA 与视网膜测量值之间无显著相关性。在没有 DR 的情况下，较长糖尿病病程的患者 mfERG 可检测到早期视网膜功能改变，但 OCT 测量的视网膜厚度无差异。
