成年男性和女性之间神经视网膜功能的差异。
Differences in neuroretinal function between adult males and females.
作者信息
Ozawa Glen Y, Bearse Marcus A, Harrison Wendy W, Bronson-Castain Kevin W, Schneck Marilyn E, Barez Shirin, Adams Anthony J
机构信息
*OD †PhD ‡OD, PhD, FAAO §PhD, RN ∥MD University of California, Berkeley School of Optometry, Berkeley, California (GO, MAB, KWB-C, MES, SB, AJA); and Midwestern University, Arizona College of Optometry, Glendale, Arizona (WWH).
出版信息
Optom Vis Sci. 2014 Jun;91(6):602-7. doi: 10.1097/OPX.0000000000000255.
PURPOSE
To determine whether neuroretinal function differs in healthy adult males and females younger and older than 50 years.
METHODS
This study included one eye from each of 50 normal subjects (29 females and 21 males). Neuroretinal function was assessed using first-order P1 implicit times (ITs) and N1-P1 amplitudes (AMPs) obtained from photopic multifocal electroretinograms. To assess local differences, retinal maps of local IT and (separately) AMP averages were constructed for each subject group. To examine global differences, each subject's 103 ITs and (separately) AMPs were also averaged to create whole-eye averages. Subsequently, retinal maps and whole-eye averages of one subject group were compared with those of another.
RESULTS
In subjects younger than 50 years, neuroretinal function differed significantly between the males and females: local ITs were significantly shorter at 83 of 103 tested retinal locations, and whole-eye IT averages were shorter (p = 0.015) in the males compared with the females. In contrast, no analysis indicated that the males and females older than 50 years were significantly different. A subanalysis showed that the females who reported a hysterectomy (n = 5) had the longest whole-eye ITs of all subject groups (p ≤ 0.0013). In the females who did not report a hysterectomy, neuroretinal function was worse in the females older than 50 years compared with the females younger than 50 years: local ITs were significantly longer at 62 of 103 retinal locations tested, and whole-eye IT averages tended to be greater (p = 0.04). Conversely, ITs were not statistically different between the younger and older males. N1-P1 amplitudes did not differ between the sexes.
CONCLUSIONS
Multifocal electroretinogram IT differs between males and females, depending on the age group and hysterectomy status.
目的
确定50岁及以上和50岁以下健康成年男性与女性的神经视网膜功能是否存在差异。
方法
本研究纳入了50名正常受试者（29名女性和21名男性）的单眼。使用从明视多焦视网膜电图获得的一阶P1隐含时间（ITs）和N1 - P1振幅（AMPs）评估神经视网膜功能。为评估局部差异，为每个受试者组构建局部IT和（分别）AMP平均值的视网膜图。为检查整体差异，还对每个受试者的103个ITs和（分别）AMPs进行平均以创建全眼平均值。随后，将一个受试者组的视网膜图和全眼平均值与另一个受试者组的进行比较。
结果
在50岁以下的受试者中，男性和女性的神经视网膜功能存在显著差异：在103个测试视网膜位置中的83个位置，局部ITs在男性中显著短于女性，并且男性的全眼IT平均值比女性短（p = 0.015）。相比之下，没有分析表明50岁及以上的男性和女性存在显著差异。一项亚分析显示，报告子宫切除术的女性（n = 5）在所有受试者组中全眼IT最长（p≤0.0013）。在未报告子宫切除术女性中，50岁及以上女性的神经视网膜功能比50岁以下女性差：在103个测试视网膜位置中的62个位置，局部ITs显著更长，并且全眼IT平均值倾向于更大（p = 0.04）。相反，年轻男性和年长男性的ITs在统计学上没有差异。N1 - P1振幅在性别之间没有差异。
结论
多焦视网膜电图IT在男性和女性之间存在差异，这取决于年龄组和子宫切除术状态。
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