Glassock Richard J
8 Bethany, Laguna Niguel, CA 92677, USA.
Clin Exp Nephrol. 2004 Dec;8(4):291-6. doi: 10.1007/s10157-004-0316-9.
The prevalence of end-stage renal disease (ESRD) is rising throughout the developed and developing world, although the rate of increase may be attenuating in some regions. Type 2 diabetes mellitus, often a consequence of obesity and accompanied by the metabolic syndrome, is a major cause of progressive renal disease and the increasing global burden of ESRD. Strategies that are cost-effective and applicable at the community level are urgently needed to stem the tide of both type 2 diabetes and the resulting ESRD. Primary and secondary prevention measures, involving screening and interventions, have demonstrated beneficial effects when appropriately designed and targeted to "high-risk" groups. If these strategies can be implemented at the societal level and compliance with the interventions is robust, it is entirely possible that the rising tide of ESRD can be converted into a receding tide of ESRD in the future.
在发达国家和发展中国家，终末期肾病（ESRD）的患病率都在上升，不过在某些地区，其上升速度可能正在减缓。2型糖尿病通常是肥胖的结果，并伴有代谢综合征，是进行性肾病和全球ESRD负担不断增加的主要原因。迫切需要具有成本效益且适用于社区层面的策略，以阻止2型糖尿病及其导致的ESRD的蔓延趋势。涉及筛查和干预的一级和二级预防措施，在经过适当设计并针对“高危”群体时，已显示出有益效果。如果这些策略能够在社会层面得到实施，并且对干预措施的依从性良好，那么完全有可能在未来将ESRD不断上升的趋势转变为下降趋势。
