Yanagita Motoko
Yanagisawa Orphan Receptor Project, Exploratory Research for Advanced Technology, Japan Science and Technology Agency, National Museum of Emerging Science and Innovation, Tokyo, Japan.
Clin Exp Nephrol. 2004 Dec;8(4):304-9. doi: 10.1007/s10157-004-0305-z.
The product of growth arrest-specific gene 6 (Gas6) is a unique vitamin K-dependent autocrine growth factor for mesangial cells, and warfarin inhibits mesangial cell proliferation by interfering with the activation process of Gas6. A recent series of studies has revealed the in vivo roles of Gas6 and its receptor Axl in the progression of acute and chronic glomerulonephritis, diabetic nephropathy, chronic allograft rejection, and human kidney diseases. This review summarizes these studies and discusses the possible interventions targeting the Gas6/Axl pathway to prevent the progression of kidney diseases.
生长抑制特异性基因6（Gas6）的产物是一种独特的、维生素K依赖性的系膜细胞自分泌生长因子，华法林通过干扰Gas6的激活过程来抑制系膜细胞增殖。最近一系列研究揭示了Gas6及其受体Axl在急性和慢性肾小球肾炎、糖尿病肾病、慢性移植肾排斥反应及人类肾脏疾病进展中的体内作用。本综述总结了这些研究，并讨论了针对Gas6/Axl途径预防肾脏疾病进展的可能干预措施。
