Schaf Débora V, Tort Adriano B L, Fricke Daniele, Schestatsky Pedro, Portela Luis V C, Souza Diogo O, Rieder Carlos R M
Departamento de Bioquímica, ICBS, UFRGS, Ramiro Barcelos 2600 - ANEXO, 90035-003 Porto Alegre, RS, Brazil.
Parkinsonism Relat Disord. 2005 Jan;11(1):39-43. doi: 10.1016/j.parkreldis.2004.07.002.
We evaluated S100B protein and neuron-specific enolase (NSE) serum levels in Parkinson's disease (PD) patients and their correlation with the severity of disease. The levels of S100B (P=0.16) and NSE (P=0.39) between PD and controls were similar. However, S100B levels correlated positively with the Hoehn and Yahr scale (r=0.368; P=0.02) and negatively with the Activities of Daily Living (ADL) scale (r=-0.431; P=0.006). Therefore, S100B and NSE may not have a diagnostic role in PD, but S100B may have a potential role as a marker of disease progression. The study of S100B may also contribute to elucidate the controversial role of glial cells in PD.
我们评估了帕金森病（PD）患者血清中S100B蛋白和神经元特异性烯醇化酶（NSE）水平及其与疾病严重程度的相关性。PD患者与对照组之间的S100B水平（P = 0.16）和NSE水平（P = 0.39）相似。然而，S100B水平与Hoehn和Yahr分级呈正相关（r = 0.368；P = 0.02），与日常生活活动（ADL）量表呈负相关（r = -0.431；P = 0.006）。因此，S100B和NSE可能在PD中不具有诊断作用，但S100B可能作为疾病进展的标志物具有潜在作用。对S100B的研究也可能有助于阐明神经胶质细胞在PD中存在争议的作用。
