Kiran Ravi P, Pokala Naveen, Burgess Phillip
Department of Surgery, Great Western Hospital, Swindon, Wiltshire, United Kingdom.
Am J Surg. 2004 Dec;188(6):708-13. doi: 10.1016/j.amjsurg.2004.08.043.
This study evaluates laser ablation of large polyps and cancer of the rectum in poor-risk surgical patients.
We performed a retrospective review of treatment of rectal lesions with the neodymium yttrium aluminium garnet (Nd:YAG) laser. Biopsy was performed before the first and subsequent therapies. Large lesions were initially debulked by diathermy snare. Biopsies were performed on suspicious areas at follow-up after completion of therapy.
Three patients with unresectable rectal cancer had symptom control over a mean period of 15.7 months and 12 patients with large polyps over 60.6 months since the start of therapy. Indications in polyps were carpeting of the rectum (n = 3), proximity to sphincter (n = 1), or comorbidity (n = 8). No complication occurred; however, there was 1 treatment failure. None of the patients with polyps developed cancer during a mean follow-up interval of 14 months after final treatment.
Outpatient laser therapy is safe, repeatable, and effective in the local control of rectal lesions.
本研究评估了激光消融术对手术风险高的直肠大息肉和癌症患者的疗效。
我们对钕钇铝石榴石(Nd:YAG)激光治疗直肠病变进行了回顾性研究。在首次及后续治疗前进行活检。大的病变最初采用电凝圈套器减瘤。治疗结束后的随访中,对可疑区域进行活检。
3例无法切除的直肠癌患者自治疗开始后平均15.7个月症状得到控制,12例大息肉患者自治疗开始后平均60.6个月症状得到控制。息肉的治疗指征包括直肠广泛受累(n = 3)、靠近括约肌(n = 1)或合并症(n = 8)。未发生并发症;然而,有1例治疗失败。息肉患者在最终治疗后的平均14个月随访期内均未发生癌变。
门诊激光治疗在局部控制直肠病变方面安全、可重复且有效。