Franz Paris, Wang Xiaomei, Zhu Hui, Chia Ray, Hasenberg Tom, Wang Hui
Department of Chemical, Paper and Biomedical Engineering, Miami University, OH 45056, USA.
Currently with Department of Applied Physics, Stanford University, CA, USA.
Biomed Opt Express. 2020 Jan 14;11(2):791-800. doi: 10.1364/BOE.376141. eCollection 2020 Feb 1.
Laser-tissue vaporization through a fiber catheter is evolving into a major category of surgical operations to remove diseased tissue. Currently, during a surgery, the surgeon still relies on personal experience to optimize surgical techniques. Monitoring tissue temperature during laser-tissue vaporization would provide important feedback to the surgeon; however, simple and low-cost temperature sensing technology, which can be seamlessly integrated with a fiber catheter, is not available. We propose to monitor tissue temperature during laser-tissue vaporization by detecting blackbody radiation (BBR) between 1.6 µm-1.8 µm, a relatively transparent window for both water and silica fiber. We could detect BBR after passing through a 2-meter silica fiber down to ∼70°C using lock-in detection. We further proved the feasibility of the technology through ex vivo tissue studies. We found that the BBR can be correlated to different tissue vaporization levels. The results suggest that this simple and low-cost technology could be used to provide objective feedback for surgeons to maximize laser-tissue vaporization efficiency and ensure the best clinical outcomes.
通过光纤导管进行激光组织汽化正逐渐发展成为去除病变组织的一类主要外科手术。目前，在手术过程中，外科医生仍依赖个人经验来优化手术技术。在激光组织汽化过程中监测组织温度将为外科医生提供重要反馈；然而，尚无能够与光纤导管无缝集成的简单且低成本的温度传感技术。我们建议通过检测1.6 µm - 1.8 µm之间的黑体辐射（BBR）来监测激光组织汽化过程中的组织温度，这对于水和石英光纤来说是一个相对透明的窗口。使用锁相检测，我们能够在通过2米长的石英光纤后检测到低至约70°C的BBR。我们通过离体组织研究进一步证明了该技术的可行性。我们发现BBR可以与不同的组织汽化水平相关联。结果表明，这种简单且低成本的技术可用于为外科医生提供客观反馈，以最大化激光组织汽化效率并确保最佳临床结果。
