Kida Aiko, Ohashi Kazuteru, Kobayashii Takeshi, Sakai Miwa, Yamashita Takuya, Akiyama Hideki, Kishida Shuji, Sakamaki Hisashi
Hematology Division, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan.
Pathol Oncol Res. 2004;10(4):204-6. doi: 10.1007/BF03033761. Epub 2004 Dec 27.
Calcineurin-inhibitor induced pain syndrome (CIPS) is a newly described entity with a characteristic feature of sudden onset of severe lower limb pain, and high levels of cyclosporine or tacrolimus may be involved in the pathogenesis. This syndrome is rarely seen in recipients of hematopoietic stem cell transplantation (HSCT) compared with other organ transplant recipients, however, heightened awareness of this complication after HSCT may be needed for hematologists, as misdiagnosis can result in catastrophic consequences. We report herein two cases of lower limb pain syndrome, with some clinical features resembling CIPS, occurring during the early phase of cord blood stem cell transplantation for hematological malignancy.
钙调神经磷酸酶抑制剂诱导的疼痛综合征（CIPS）是一种新描述的病症，其特征为突然发作的严重下肢疼痛，发病机制可能与高水平的环孢素或他克莫司有关。与其他器官移植受者相比，这种综合征在造血干细胞移植（HSCT）受者中很少见，然而，血液科医生可能需要提高对HSCT后这种并发症的认识，因为误诊可能导致灾难性后果。我们在此报告两例下肢疼痛综合征病例，在血液系统恶性肿瘤的脐血干细胞移植早期出现，一些临床特征类似于CIPS。
