Naredo Sánchez E, Balsa Criado A, Sanz Guajardo A, Pantoja Zarza L, Martín Mola E, Gijón Baños J
Department of Rheumatology, La Paz Hospital, Autónoma University of Madrid, Spain.
Clin Exp Rheumatol. 1994 Nov-Dec;12(6):653-6.
A leg bone pain syndrome of unclear etiology has been recently described in renal transplant patients receiving cyclosporine A. Herein we report a 54-year-old woman treated with cyclosporine A (CsA), corticosteroids and azathioprine who developed two months after renal transplantation severe symmetric pain with periarticular soft tissue swelling in the knees and metatarsophalangeal joints. Scintigraphy showed periarticular radionuclide activity. Clinical onset was associated with both the high dosage and with the plasma levels of CsA. Symptoms improved when the dosage of CsA was reduced and the plasma levels declined to less than 150 ng/ml.
最近在接受环孢素A治疗的肾移植患者中发现了一种病因不明的腿部骨痛综合征。在此，我们报告一名54岁女性，她接受了环孢素A（CsA）、皮质类固醇和硫唑嘌呤治疗，肾移植两个月后出现严重的对称性疼痛，膝关节和跖趾关节周围软组织肿胀。闪烁扫描显示关节周围有放射性核素活性。临床发病与CsA的高剂量和血浆水平有关。当CsA剂量减少且血浆水平降至低于150 ng/ml时，症状有所改善。
