Ye Q, Tong J, Shi M, Bao G
Qinhuangdao hygiene and Antiepidemic Station 066000.
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 1997 Mar;11(1):37-40.
This article described a seroepidemiological surveillance in 326 patients with different clinical types of liver disease (acute hepatitis, AH; chronic hepatitis, CH; liver cirrhosis, LC; hepatocellular carcinoma, HCC) from hospitals in Qinhuangdao city during 1992-1995. The results showed that HAV infection could not develop chronic hepatitis. Among 238 patients of CH, LC, and HCC, anti-HAV IgM was not detected. HBV infection was the main pathogenic factor of CH, LC, and HCC with an infection rates of 77.78%, 84.21%, and 94.29%, respectively, the average rate of infection was 3.8 times higher than that in AH. HCV infection rate was increased gradually with development of chronic liver syndrome. Anti-HCV positive rate was 5.56% in CH, but 14.74% and 20.00% in LC and HCC respectively. HEV infection was found in patients with all types of liver disease with an average positive rate of 13.19%. It was not found that single HEV infection developed in CH, LC, and HCC. The average rate of super infection was 17.18% among all the patients, but the super infection rate in LC and HCC was 1.93 times higher than that in AH and CH. It seems that the super infection of HBV and HCV was the main factor for worsened liver symptoms and for developing LC and HCC.
本文描述了1992 - 1995年期间对秦皇岛市各医院326例不同临床类型肝病（急性肝炎，AH；慢性肝炎，CH；肝硬化，LC；肝细胞癌，HCC）患者进行的血清流行病学监测。结果显示，甲型肝炎病毒（HAV）感染不会发展为慢性肝炎。在238例慢性肝炎、肝硬化和肝细胞癌患者中，未检测到抗HAV IgM。乙型肝炎病毒（HBV）感染是慢性肝炎、肝硬化和肝细胞癌的主要致病因素，感染率分别为77.78%、84.21%和94.29%，平均感染率比急性肝炎高3.8倍。丙型肝炎病毒（HCV）感染率随着慢性肝病综合征的发展而逐渐升高。慢性肝炎患者抗HCV阳性率为5.56%，但肝硬化和肝细胞癌患者分别为14.74%和20.00%。戊型肝炎病毒（HEV）感染在所有类型肝病患者中均有发现，平均阳性率为13.19%。未发现单一戊型肝炎病毒感染在慢性肝炎、肝硬化和肝细胞癌中发展。所有患者中重叠感染的平均发生率为17.18%，但肝硬化和肝细胞癌中的重叠感染率比急性肝炎和慢性肝炎高1.93倍。似乎乙型肝炎病毒和丙型肝炎病毒的重叠感染是肝脏症状恶化以及发展为肝硬化和肝细胞癌的主要因素。
