Imamura M, Gipson T G, Bensky N, Justice R, Martin W J
J Immunol. 1979 May;122(5):1863-6.
The tumor-associated transplantation antigen expressed by several transplacentally induced lung tumors of C3HfeB/HeN mice (H-2kb haplotype) has previously been shown to exist as a normal tissue alloantigen in mice of known H-2k and H-2a haplotypes. This antigen is not expressed in normal tissues of C3HfeB/HeN mice but is expressed in C3H/HeN mice, the strain from which the C3HfeB/HeN mice were originally derived. The present study indicates that spleen cells from C3HfeB/HeN and C3H/HeN mice respond reciprocally in the mixed lymphocyte reaction. Cytotoxic T lymphocytes specific for the tumor-associated alloantigen can be readily generated in mixed lymphocyte reactions in which spleen cells from C3HfeB/HeN mice are reacted with x-irradiated spleen cells from C3H/HeN or A strain mice. These cells are effective in suppressing the growth of the C3HfeB/HeN-derived lung tumor 85 in x-irradiated syngeneic recipients.
几种经胎盘诱导的C3HfeB/HeN小鼠（H-2kb单倍型）肺肿瘤所表达的肿瘤相关移植抗原，先前已被证明在已知H-2k和H-2a单倍型的小鼠中作为正常组织同种抗原存在。这种抗原在C3HfeB/HeN小鼠的正常组织中不表达，但在C3H/HeN小鼠中表达，C3HfeB/HeN小鼠最初源自该品系。本研究表明，C3HfeB/HeN和C3H/HeN小鼠的脾细胞在混合淋巴细胞反应中相互应答。在混合淋巴细胞反应中，当C3HfeB/HeN小鼠的脾细胞与经X射线照射的C3H/HeN或A品系小鼠的脾细胞反应时，可容易地产生针对肿瘤相关同种抗原的细胞毒性T淋巴细胞。这些细胞在经X射线照射的同基因受体中可有效抑制源自C3HfeB/HeN的肺肿瘤85的生长。
