Martin W J, Gipson T G, Conliffe M A, Cotton W G, Dove L F, Rice J M
J Immunogenet. 1978 Aug;5(4):255-60. doi: 10.1111/j.1744-313x.1978.tb00653.x.
A transplacentally induced lung tumour of C3HfeB/HeN mouse origin expresses, as a tumour-associated antigen, a normal tissue component of strain A mice. The genetic locus coding for this alloantigen has been shown to be linked to the H-2 major histocompatibility complex. In the present study we demonstrate that this antigen is also expressed on normal tissues of C3H/HeN mice. Skin grafts exchanged between C3HfeB/HeN and C3H/HeN mice are reciprocally rejected at approximately 3 weeks after grafting. C3HfeB/HeN mice were derived from C3H/HeN mice in 1945. These strains have apparently deviated since then in their genetic regulation of the expression of the MHC-linked genetic locus. The finding of the C3H/HeN-associated antigen on a C3HfeB/HeN mouse-derived lung tumour indicates that this deviation is reversible.
源自C3HfeB/HeN小鼠的经胎盘诱导的肺肿瘤表达一种A系小鼠的正常组织成分，作为肿瘤相关抗原。编码这种同种异体抗原的基因座已被证明与H-2主要组织相容性复合体连锁。在本研究中，我们证明这种抗原也在C3H/HeN小鼠的正常组织上表达。C3HfeB/HeN和C3H/HeN小鼠之间交换的皮肤移植在移植后约3周相互排斥。C3HfeB/HeN小鼠于1945年从C3H/HeN小鼠衍生而来。从那时起，这些品系在MHC连锁基因座表达的遗传调控方面显然已经发生了偏差。在源自C3HfeB/HeN小鼠的肺肿瘤上发现C3H/HeN相关抗原表明这种偏差是可逆的。
