[两名急性髓系白血病患者中以双8;21易位为特征的四倍体克隆]
[Tetraploid clones characterized by double 8;21 translocations in two patients with acute myeloid leukemia].
作者信息
Xue Y, Pan Y, Liu Z, Guo Y, Xie X
机构信息
Jiangsu Institute of Hematology, First Affiliated Hospital of Suzhou Medical College, Suzhou 215006.
出版信息
Zhonghua Xue Ye Xue Za Zhi. 1997 May;18(5):240-2.
OBJECTIVE
To report two cases of leukemia with t(8;21) and tetraploid clones.
METHODS
R-banding technique was used.
RESULTS
Cytogenetic studies of BM cells at diagnosis revealed that each of the two cases had three related abnormal clones besides a normal one: 46, XY, t(8;21) (2%), 46, idem, add((7)(q31)(6.8%) and 92, idem x 2 (80.6%) in case 1 and 46, XX, t(8;21) (13.4%), 47, idem, + 4 (46.3%) and 94, idem x 2 (39.1%) in case 2. They did not obtain complete remission on chemotherapy and survived 4 and 6 months, respectively.
CONCLUSION
Tetraploid or near tetraploid clones are secondary events which are specifically associated with t(8;21) leukemia and the prognosis of patients with this kind of abnormal karyotype is poor.
目的
报告2例伴有t(8;21)和四倍体克隆的白血病病例。
方法
采用R显带技术。
结果
诊断时对骨髓细胞进行的细胞遗传学研究显示，2例病例除正常克隆外，各有3个相关异常克隆：病例1为46, XY, t(8;21) (2%)、46, 同前, add((7)(q31)(6.8%)和92, 同前x2 (80.6%)；病例2为46, XX, t(8;21) (13.4%)、47, 同前, +4 (46.3%)和94, 同前x2 (39.1%)。他们化疗后未获完全缓解，分别存活4个月和6个月。
结论
四倍体或近四倍体克隆是继发事件，与t(8;21)白血病特异性相关，具有这种异常核型的患者预后较差。
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