Bellamy K E, Waters M G J
Department of Dental Health and Biological Sciences, University of Wales College of Medicine, Cardiff, UK.
Biomed Mater Eng. 2005;15(1-2):21-7.
The materials which are currently used to make maxillofacial prostheses are far from ideal and require considerable improvement with respect to their ability to mimic the properties of skin. To this aim, a novel three-layered maxillofacial prosthesis has been designed consisting of a silicone rubber base layer, an inner gel layer and an outer polymeric coating (to simulate the elastic properties of skin). The aim of the work in this study was to develop the inner silicone gel layer which displays similar properties to facial skin. Through the use of unique linear extensometry testing, in vivo measurements for the Area under the Curve (AUC), Hysteresis (viscoelastic behaviour), Fmax (maximum force), F30 and F60 (force after 30 and 60 seconds) were obtained from the facial skin of 15 volunteers. The results were used as a basis for developing silicone gel formulations for the inner layer, to closely resemble those of facial skin. Gels were made by the addition of both low and high molecular weight unreactive silicone fluids and were further tested for compression, water absorption and dehydration. Testing showed that a gel has been produced that closely simulates the elastic properties of skin when bonded to a base silicone rubber layer. Further testing will need to deduce whether these properties will be affected by the addition of the outer polymeric layer.
目前用于制造颌面修复体的材料远非理想，在模仿皮肤特性方面需要大幅改进。为此，设计了一种新型三层颌面修复体，它由硅橡胶基层、内部凝胶层和外部聚合物涂层组成（以模拟皮肤的弹性特性）。本研究的目的是开发出具有与面部皮肤相似特性的内部硅胶凝胶层。通过使用独特的线性伸长率测试，从15名志愿者的面部皮肤获取了曲线下面积（AUC）、滞后现象（粘弹性行为）、最大力（Fmax）、F30和F60（30秒和60秒后的力）的体内测量值。这些结果被用作开发内层硅胶凝胶配方的基础，使其与面部皮肤的配方极为相似。凝胶是通过添加低分子量和高分子量的非反应性硅油制成的，并进一步进行了压缩、吸水和脱水测试。测试表明，当与基层硅橡胶层结合时，已制成一种能紧密模拟皮肤弹性特性的凝胶。还需要进一步测试来推断这些特性是否会受到外部聚合物层添加的影响。
