功能化氧杂杯[4]芳烃的合成。

Synthesis of functionalized oxacalix[4]arenes.

作者信息

Katz Jeffrey L, Feldman Michael B, Conry Rebecca R

机构信息

Department of Chemistry, Colby College, 5754 Mayflower Hill, Waterville, Maine 04901, USA.

出版信息

Org Lett. 2005 Jan 6;7(1):91-4. doi: 10.1021/ol047840t.

DOI:10.1021/ol047840t

PMID:15624985

Abstract

Tetranitrooxacalix[4]arenes are generated in high yield by the room-temperature S(N)Ar reaction of 1,3-dihydroxybenzenes with 1,5-difluoro-2,4-dinitrobenzene. The reaction is tolerant to a range of functionality on the nucleophilic component, including hydroxyl-substitution at the 2- and 5-positions, which yields previously unknown 26,28- and 5,17-dihydroxyoxacalix[4]arenes.

摘要

通过1,3 - 二羟基苯与1,5 - 二氟 - 2,4 - 二硝基苯在室温下的S(N)Ar反应可高产率生成四硝基氧杂杯[4]芳烃。该反应对亲核组分上的一系列官能团具有耐受性，包括2 - 位和5 - 位的羟基取代，这产生了以前未知的26,28 - 二羟基氧杂杯[4]芳烃和5,17 - 二羟基氧杂杯[4]芳烃。