Wolff D G
Department of Pharmacology, University of Southern California, School of Medicine, Los Angeles, California 90033, USA.
Biochem Biophys Res Commun. 1976 Dec 20;73(4):850-7. doi: 10.1016/0006-291x(76)90199-6.
The evolution of carbon monoxide during lipid peroxidation has been demonstrated in microsomal membranes. The formation of carbon monoxide was dependent on the peroxidation process, but independent of the initiators (NADPH-ADP x Fe(+3) or Ascorbate-Fe(+3)) used. Contrary to published results, the carbon monoxide does not result from heme catabolism. Carbon monoxide was generated during the peroxidation of isolated phospholipids, indicating that carbon monoxide may form directly during the peroxidative degradation of unsaturated fatty acids.
脂质过氧化过程中一氧化碳的生成已在微粒体膜中得到证实。一氧化碳的形成依赖于过氧化过程，但与所使用的引发剂（NADPH - ADP x Fe(+3)或抗坏血酸 - Fe(+3)）无关。与已发表的结果相反，一氧化碳并非来自血红素分解代谢。一氧化碳在分离的磷脂过氧化过程中生成，这表明一氧化碳可能在不饱和脂肪酸的过氧化降解过程中直接形成。
