Yoshinaga Harumi, Koutroumanidis Michael, Shirasawa Atsushi, Kikumoto Kenichi, Ohtsuka Yoko, Oka Eiji
Department of Child Neurology, Okayama University Medical School, Shikatacho 2-5-1, Okayama 700-8558, Japan.
Brain Dev. 2005 Jan;27(1):46-52. doi: 10.1016/j.braindev.2004.04.005.
Panayiotopoulos syndrome (PS) is a type of benign childhood partial epilepsy, which has a good prognosis despite the fact that it is frequently associated with abundant multifocal spikes on the electroencephalography (EEG). We investigated whether stable dipoles, as seen in rolandic epilepsy, were also present in PS. We performed dipole analysis of the interictal spike discharges seen in the interictal EEGs of eight children with PS. We chose more than 10 spikes for each kind of spike, and investigated whether or not more than three of these spikes showed consistently stable dipole locations. (1) We observed 15 different kinds of spikes in various regions in the EEGs of the eight children. (2) Twelve of the 15 kinds of spikes had dipoles with a high goodness of fit. Furthermore, 14 of the 15 spikes had stable dipoles with similar locations for more than three individual spikes. (3) Fourteen of the 15 spikes, including frontal spikes, showed dense dipole locations in the mesial occipital area. Thirteen of these 14 spikes also showed other dipole locations in the rolandic area and/or the vertex (Cz). Our study revealed that the various types of spikes observed in PS have similar and stable dipole locations. The dipoles showing high stability, were located in the mesial occipital area, and were accompanied by dipoles located in the rolandic area. The stability and location of these dipoles indicate that there may be a pathogenetic link between PS and rolandic epilepsy.
帕纳约托普洛斯综合征（PS）是一种儿童期良性部分性癫痫，尽管其在脑电图（EEG）上常伴有大量多灶性棘波，但预后良好。我们研究了在罗兰多癫痫中所见的稳定偶极子在PS中是否也存在。我们对8例PS患儿发作间期EEG中的发作间期棘波放电进行了偶极子分析。我们为每种棘波选取了10多个棘波，并研究这些棘波中是否有超过3个显示出一致稳定的偶极子位置。（1）我们在8例患儿的EEG不同区域观察到15种不同类型的棘波。（2）15种棘波中的12种具有拟合优度高的偶极子。此外，15个棘波中的14个具有稳定的偶极子，超过3个单个棘波的偶极子位置相似。（3）15个棘波中的14个，包括额部棘波，在枕叶内侧区域显示出密集的偶极子位置。这14个棘波中的13个在罗兰多区域和/或头顶（Cz）也显示出其他偶极子位置。我们的研究表明，在PS中观察到的各种类型的棘波具有相似且稳定的偶极子位置。显示出高稳定性的偶极子位于枕叶内侧区域，并伴有位于罗兰多区域的偶极子。这些偶极子的稳定性和位置表明PS与罗兰多癫痫之间可能存在发病机制上的联系。
