Lin Jiehua, Ju Huangxian
Department of Chemistry, Institute of Analytical Science, State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, PR China.
Biosens Bioelectron. 2005 Feb 15;20(8):1461-70. doi: 10.1016/j.bios.2004.05.008.
The determination of serum tumor markers plays an important role in clinical diagnoses for the patients with certain tumor-associated disease. Although many commercial kits have been applied in clinical immunoassays, conventional methods always have some disadvantages, resulting in the need of other new, efficient, and easily automated methods. Immunosensors, considered as a major development in immunochemical field, have attracted considerable attention. With the aim of rapid screening, many immunosensors that are small, semi-automated and portable are being developed. This brief review focuses on the current research of immunosensors for tumor markers based on the electrochemical and chemiluminescent detection with emphasis on recent advances, challenges, and trends. The works on series of novel immunosensors developed for the determination of tumor markers in our group in the last few years are also introduced.
血清肿瘤标志物的测定在某些肿瘤相关疾病患者的临床诊断中起着重要作用。尽管许多商业试剂盒已应用于临床免疫分析，但传统方法总是存在一些缺点，因此需要其他新的、高效的且易于自动化的方法。免疫传感器作为免疫化学领域的一项重大发展，已引起了相当大的关注。为了实现快速筛查，许多小型、半自动且便携的免疫传感器正在被开发。本简要综述聚焦于基于电化学和化学发光检测的肿瘤标志物免疫传感器的当前研究，重点介绍近期进展、挑战和趋势。还介绍了我们小组在过去几年中为测定肿瘤标志物而开发的一系列新型免疫传感器的相关工作。
